OverviewCENTRE FOR ADDICTION AND MENTAL HEALTH Independent Scientist Full Time in Toronto, ON
CENTRE FOR ADDICTION AND MENTAL HEALTH
Branch Toronto ON CA
Resources include animal care facilities, behavioural testing areas, molecular biology and genetics infrastructure, tissue culture, electrophysiology, confocal…
Neurobiology of Depression and Aging
It is estimated that depression affects more than 1 million Ontarians with an economic burden of over 12.5 billion every year in both direct and indirect costs. In light of the heavy socio economic burden, the Ontario government has issued a new directive to address this debilitating psychiatric illness. The Centre for Addiction and Mental Health (CAMH), Canada’s largest mental health and addiction teaching hospital, is leading the path to investigate the underlying mechanisms in depression. CAMH with endowment from the Campbell family has recently created the Campbell Research Institute, headed by the inaugural Chair – Dr. Etienne Sibille, a leader in the field of molecular neurobiology of depression. Dr. Sibille will be heading the Neurobiology of Depression and Aging Department, which focuses on investigating the underlying molecular mechanism for depression and aging and their respective treatments with the goals of identifying new targets for treatment. Resources include animal care facilities, behavioural testing areas, molecular biology and genetics infrastructure, tissue culture, electrophysiology, confocal microscope, and a wide array of basic and clinical expertise. The department and CAMH, is currently seeking an outstanding scientist who is dedicated to advancing the knowledge in the underlying mechanisms of depression and establishing a drug development program for discovering new mechanisms of actions of neuropsychiatric compounds . The ideal candidate should have a PhD in Cellular and Molecular Neurobiology with expertise in major depressive disorders (MDD) and drug discovery in MDD. The candidate should have significant experience working with rodent models of depression with a special focus on performing proof-of-concept studies for the development of novel antidepressant treatments with new mechanisms of action. This will require a strong background in pharmacology, genetic manipulation and behavioral/molecular testing in rodent models, as well as in testing mechanisms in cell-based systems. The candidate should also have in-depth scientific expertise with mechanisms of neuropsychiatric disorders and of their antidepressant treatments, and working experience with chronic stress models, a precipitating factor in MDD, specifically focusing on the behavioural, structural and region- and cell-specific changes induced by chronic stress. Prior evidence of collaborative work with pharmaceutical company novel drug development programs would be a plus. The candidate should also have experience using viral vector and transgenic approaches. The candidate should also demonstrate expertise in linking the rodent research with primary pathological findings performed in humans, such as in the postmortem brain. The overarching goals are to identify novel targets and pharmacological agents and develop robust sets of experiments to support the rapid translation of findings into putative drug development in human subjects (i.e., bench-to-bedside translation).
The ideal candidate should have an excellent record of scientific accomplishments, complemented by strong interpersonal, organizational and communication skills. The successful applicant will be expected to work independently, but in close complement with other scientists in the Neurobiology of Depression and Aging group. The applicant will demonstrate a commitment to conducting and fostering research and enthusiasm regarding participating in multidisciplinary research and training activities.
You will support a healthy workplace that embraces diversity, encourages teamwork and complies with all applicable regulatory and legislative requirements. This position is located at 250 College Street, Toronto, Ontario, Canada.
The Centre for Addiction and Mental Health is fully affiliated with the University of Toronto and is located within the vibrant Toronto biomedical research community. The successful candidate will be eligible for cross-appointment to a faculty position at the University of Toronto.
The successful candidate should have a PhD in Cellular and Molecular Neurobiology with expertise in major depressive disorders (MDD). 4+ years of independent research experience. The candidate should have significant experience working with rodent models of depression and in-depth scientific expertise with mechanisms of neuropsychiatric disorders and of their antidepressant treatments. High degree of experience working using brain surgery for local region specific administration of drugs and viruses in rodents is a must. The candidate should have a strong background in screening of novel compounds with antidepressant properties in rodent models of anxiety, depression and stress specifically assessment of dose response, behavioral changes and cellular changes following drug administrations. Prior evidence of collaborative work with pharmaceutical company novel drug development programs would be a plus. The candidate should have working experience with chronic stress models, viral and transgenic approaches and cell-specific changes induced by chronic stress. Additionally the candidate should have expertise in cellular and molecular techniques using both human post mortem and rodent brain samples assessing specifically the signaling cascades altered in depression. The successful candidate will have a track record that demonstrates competence in obtaining grants, publishing in high impact peer reviewed journals, disseminating research at formal scientific meetings, and participation in the education of students and trainees. Consistent with the expectation that all Scientists seek to apply their research findings into practice, the successful candidate will be required to work towards this end. The ability to interact with populations of diverse ethnoracial and cultural backgrounds is also required. Bilingualism (English/French) and/or proficiency in a second language is considered an asset. The candidate is also expected to obtain a faculty appointment at the University of Toronto.
Please note: This full-time position is NOT part of any bargaining unit. Salary Range: $43.87 to $51.61 Hourly, 37.50 Hours per week, Pension Plan Benefits Please click the link below to apply:
CAMH is a Tobacco-Free Organization.
CAMH is fully affiliated with the University of Toronto and is a teaching hospital and research institute. As a CAMH employee you will be expected to actively support CAMH’s teaching and research activities, in addition to supporting the clinical work of the hospital.
As an employment equity employer CAMH actively seeks Aboriginal peoples, visible minorities,
women, people with disabilities, (including people who have experienced mental health and
substance use challenges), and additional diverse identities for our workforce.
We thank all applicants for their interest, however, only those selected for an interview will be contacted.
If contacted for an interview, please inform us should accommodation be required.
All applicants are welcome to apply, however preference will be given to Canadian citizens.
Employment Type: Full Time
Location: Toronto, ON, CA
Posted on: 2015-05-24