Aquinox Pharmaceauticals Inc. DMPK/Bio-Analytical Scientist Full Time in Vancouver, BC

Aquinox Pharmaceauticals Inc.

Branch Vancouver BC CA

DMPK/Bio-Analytical Scientist
Vancouver, BC

Is a virtual biotech company working with global CROs and CMOs. Aquinox Pharmaceuticals, Inc….

About Aquinox:

Aquinox Pharmaceuticals, Inc. is a late clinical-stage pharmaceutical company discovering and developing targeted therapeutics in disease areas of inflammation and immuno-oncology. Our primary focus is anti-inflammatory product candidates targeting SH2-containing inositol-5′-phosphatase 1, or SHIP1, which is a key regulator of an important cellular signaling pathway in immune cells, known as the PI3K pathway. Aquinox’s lead drug candidate, AQX-1125, is a small molecule activator of SHIP1 suitable for oral, once daily dosing. In September, 2016, we began enrolling patients in a Phase 3 clinical trial in our lead indication, Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). Other indications are under consideration for future investigation. Aquinox has a broad intellectual property portfolio and pipeline of preclinical drug candidates that activate SHIP1. For more information, please visit www.aqxpharma.com.

Aquinox is publically traded on NASDAQ (AQXP) with offices in Vancouver, BC, Canada and in San Bruno, CA, USA.

The Location of Position:

The Scientist, DMPK/Bio-Analytical position will be located in our Vancouver, BC, office.

The Opportunity:

Reporting to the Director, Non-Clinical Development, the Scientist will be involved with in-vivo and in-vitro pharmacokinetics, pharmacodynamics and drug metabolism studies working in the areas of clinical pharmacology, drug metabolism and therapeutics for existing as well as new products. Aquinox Pharmaceuticals Inc. is a virtual biotech company working with global CROs and CMOs.

Specifically, the Scientist will:

  • Design, execute, analyze the data and report results of preclinical DMPK experiments
  • Develop and validate LC-MS/MS based bioanalytical methods to support regulated bioanalysis of small molecules
  • Provide bioanalytical support for clinical activities when required
  • Collaborate with team members and cross functional team such as Quality and CMC
  • Manage external relations with CMOs and CROs to achieve objectives
  • Write SOPs and technical reports, implementing and maintaining high quality standards for all aspects of work conducted including adherence to regulatory GLP/GMP, departmental, and safety guidelines
  • Develop alternatives and solutions for a range of complex scientific problems. Solutions require creativity, critical thinking and collaboration, considering a broad range of potential impacts

What you bring:

  • At least a Bachelors in Science or Masters in Science in a biology or chemistry related discipline with at least 5 years of relevant pharmaceutical/biotechnology industry experience
  • Proven ability to independently design, conduct and interpret experiments in pharmaceutical bioanalysis (method development and validation), in vivo pharmacokinetics, in vitro and in vivo drug metabolism to meet the needs of the pharmaceutical/biotechnology industry
  • Proven ability to contribute to program DMPK strategy, study design, protocol preparation, study execution, data review/analysis, report preparation and regulatory document preparation.
  • Extensive hands-on experience and strong interpretation skills of LC-MS/MS assays for small molecule bioanalysis in a regulated environment (e.g., GLP and GCP)
  • Experience with formulation an asset
  • Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment.
  • Attention to detail and strong documentation experience required.
  • Ability to work well with a wide range of functional groups and ability to work independently

Our current clinical trials, exceptional team, and strong track record make it an excellent time to seize this exciting opportunity! We provide a collaborative and innovative environment with competitive incentive packages and rewards. Moreover, we provide the opportunity to partake in meaningful work.

Interested candidates are invited to forward their resume and cover letter indicating why you feel you are a fit for the Scientist, DMPK/Bio-Analytical role at Aquinox Pharmaceuticals, Inc.

We thank all applicants for their interest; only those chosen for an interview will be contacted.

Job Type: Full-time

or proceed with Standard Application Form.

Employment Type: Full Time
Location: Vancouver, BC, CA
Posted on: 2016-12-05
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